Organic Intermediate ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE CAS 10488-69-4
|Terms of Trade:||CIF|
|Min. Order:||1 Kilogram|
|Delivery Time:||15 Days|
|Place of Origin:||CHINA|
|Supply Ability:||TRUE MANUFACTURER|
Model No.: 10488-69-4
At present, there have been many reports on the preparation of chiral ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE by asymmetric reduction of ethyl 4-chloroacetoacetate. The main preparation methods are chemical methods and biological methods. Among them, microbial catalysis in biological methods is a hot spot of research. Microbial catalysis utilizes the stereoselectivity of a specific microbial cell-specific enzyme system to selectively convert a substrate into a product in a cell. However, due to the complexity of the enzyme system present in the cell, the optical purity of the catalytic product is not high, and it is necessary to screen an excellent microbial strain or to improve by cloning a recombinant gene. Coenzyme addition is also required to provide the reducing power of the reaction.
In the technique of preparing DL-4-chloro-3-hydroxybutyric acid ethyl ester by asymmetric reduction of ethyl 4-chloroacetoacetate by microbial catalytic method, the substrate conversion rate is low, the optical purity of the product is low, and the coenzyme cycle regeneration is solved. Need to be further studied and resolved. Someone specially designed a technical solution for this: using 4-chloroacetoacetate as a substrate, glucose as a substrate, NAD(P)+ as a cofactor, and introducing a ketoreductase gene and glucose dehydrogenation. Recombinant Escherichia coli with the enzyme GDH gene was subjected to a transformation reaction to prepare an asymmetric solution of Ethyll-4-Chloro-3-Hydroxy Butyrate. This method effectively solves various major defects in the asymmetric reduction of Ethyll-4-Chloro-3-Hydroxy Butyrate CAS 10488-69-4 microbial catalytic method.
Thera. Category: Organic intermediate
Packing: Export worthy packing
lMaterial Safety Data Sheet: Available on request
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- Company Name: Taizhou Volsen Chemical Co., Ltd.
- Representative: Mr Chen
- Product/Service: Efinaconazole Intermediates , Isavuconazole Intermediates , Obeticholic Acid Intermediates , Vilanterol Intermediates , Dolutegravir Intermediates , Umeclidinium Bromide
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